该剧根据同名Wondery播客的第三季改编，聚焦意大利胸外科医生和前再生医学研究员保罗·马基亚里尼，他因研究欺诈和操纵行为而闻名。
　　马基亚里尼被认为是使用植入患者自身干细胞作为气管移植物的生物和合成支架的先驱，他被指控不道德地进行实验性手术，导致接受他合成气管移植手术的八名患者中有七名死亡。
　　首季运作人帕特里克·马克曼努斯担任执行制作人，编剧阿什利·米歇尔·霍班接手运作，剧情描述为：马基亚里尼是一个迷人的外科医生，因其创新的手术而闻名，为他赢得了“奇迹人”的绰号。当调查记者贝尼塔·亚历山大为写报道接近他后，个人生活和工作之间的界限开始模糊，永远改变了她的生活。当她了解到保罗将如何保护他的秘密，世界另一端的一群医生做出了令人震惊的发现，这让关于“奇迹人”的一切都受到了质疑。

A morgue technician successfully reanimates the body of a little girl, but to keep her breathing, she will need to harvest biological materials from pregnant women. When the girl's mother, a nurse, discovers her baby alive, they enter into a deal that forces them both down a dark path of no return.

The Horror of Dolores Roach is a grotesque Sweeney Todd-inspired tale of Eat or Be Eaten; a macabre urban legend of love, betrayal, weed, gentrification, cannibalism, and survival of the fittest. It follows the indomitable Dolores Roach, who returns to a New York City neighborhood that has changed drastically during the sixteen years she has been in prison. Her boyfriend missing, her family long gone, Dolores is recognized only by an old stoner friend, Luis, who gives Dolores room and board and lets her give massages for cash in the basement apartment under his dilapidated empanada shop.
　　When the promise of her newfound stability is quickly threatened, ‘Magic Hands Dolores’ is driven to extremes to survive — leaving in her wake a string of strangled massage clients. In the face of unexpected professional success, Dolores and Luis become dangerously symbiotic, and Luis must unleash his own particular predilections.

在目睹一名病人诡异的创伤经验之后，萝丝·卡特医师（索茜·贝肯 饰）开始经历一些她无法解释的恐怖事件。当一股令人不寒而栗的可怕力量开始占据她的生活，萝丝就必须面对她令人不安的阴暗过去，才能够存活并逃离她充满恐惧的全新现实。

即使私底下过着艰难无依的生活，安珀·艾波顿（奥莉伊·卡拉瓦尔侯饰）在人前总是表现得乐观积极。还在念高中的她拥有优秀的音乐天赋，并梦想进入卡内基美隆大学。尽管要平衡工作、生活和一些无法告人的生活难题，她还是面带微笑地撑过去。然而，当可能危及梦想的挑战接踵而至，她必须学习依靠情同家人的朋友们，继续勇敢向前。