Mayans M.C. follows the life of Ezekiel “EZ” Reyes, president of the Mayans M.C. charter on the Cali/Mexi border. EZ has now risen to lead his brother Angel and the Santo Padre M.C. in a bloody war against their rival Sons of Anarchy. Defending the California territory and patch begins to claim lives within the club and causes strain between EZ and Angel.

第六季确定为最终季。