A global scientific summit debates and fails on a plan to stop a massive asteroid heading straight for Earth, with all countries blaming each other for the impeding disaster. With communications tense, the daughter of a tech billionaire assembles her own team of specialists to try to destroy the asteroid before it is too late.

Russian operatives hijack a commercial American jet, planning to crash it into a nuclear power plant near Washington, D.C. resulting in fallout that will devastate the Eastern seaboard. With little time for Air Force fighters to shoot it down, the passengers and crew aboard the aircraft must rely on their own military and civilian training to stop the terrorists before it's too late.

洛杉矶又受到怪物的袭击，这次袭击的怪物力量远比它们的前辈更为强大，整座城市陷入了恐慌之中，罗素博士临危受死,带领着冲锋队奋起迎战。