With the Wicked Witch of the West now vanquished from Oz, Tom and Jerry along with Dorothy are back in Kansas! But not for long as an all-new villain has surfaced from beneath the magical land, the Gnome King! Having captured the Good Witch, the Gnome King and his army are wreaking havoc throughout Oz and need but one item to take control of The Emerald City, Dorothy's ruby slippers! It's up to our favorite cat and mouse duo to team up, go Back to Oz and save the land they love. Take to the skies, courtesy of the Wizard himself, with Dorothy, Toto, the Scarecrow, the Tin Man and the Lion as they make their magical journey. The laughs and adventure will roar as they encounter all-new frights and mischievous creatures down the Yellow Brick Road, 'cause "we're not in Kansas anymore!"

鲁格拉特兹家那群出了名的闹孩子们被遗弃在波力妮西亚无人的荒岛上，这里他们遇到了跟自己非常相似的汤米，并开始了他们的野外冒险。
　　斯派克终于意识到当它跟伊莱扎说话的时候，狂吠比撕咬更能让她理解它的意思。残暴的安杰丽卡遇到了跟她旗鼓相当的黛比。胆小的查科尔在和野孩子汤尼在一起后才发现一直隐藏在自己体内的那个勇敢的男孩。吃虫子的双胞胎兄弟菲尔和利尔在见识过野外虫子世界真实的一面后后改吃了蔬菜。而汤米在与耐杰尔的比较之下，发现自己只不过是个纸上谈兵的孩子。
　　所有的事情都开始于汤米的父亲斯图带着家里人做一次家庭旅行，这次水上旅行让他们来到个荒芜的小岛。在只有美洲豹的热带他们成了这里唯一的人类。他们必须团结一致才能重新回到人类世界，鲁格拉特兹家和索恩巴里斯家变成了一个幸福的大家庭。